HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis

<div>(a) HBO1 expression was significantly decreased in HBO1 knockdown group. (b) HBO1 knockdown alleviated the liver aging. (c) The level of liver fibrosis was alleviated in HBO1 knockdown group. (d) TGF-<i>β</i> and <i>α</i>-SMA expressions were reduced. (e) HBO1 knockdown reduced the expression of proinflammatory molecules (TNF-<i>α</i> and IL6). (f) Rotarod and running wheel results show greater exercise capacity in the HBO1 knockout group that that of control group. (g) HBO1 knockdown improved on memory and learning ability of aged mice. 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Oxidative Medicine and Cellular Longevity

fig11

Figure 11

Figure 11: HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis 