Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia

Figure 3

Effects of LXR agonist (GW3965) on Idol expression and lipid metabolism in hamsters. (a, b) The effect of GW3965 on the expression of Idol in the liver (a) and small intestine (b). -7, ^#. (c, d) The effect of GW3965 on the mRNA expression of Srebp1c, Scd1, and Cetp in the liver (c) and small intestine (d). -7, ^#; ^##. (e) The effect of 7-day oral administration of GW3965 (15 mg/kg) on plasma TC, LDL-C, HDL-C, and TG levels. /group, ^#; .

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