Nur77 Deficiency Exacerbates Macrophage NLRP3 Inflammasome-Mediated Inflammation and Accelerates Atherosclerosis

<div>Effect of Nur77 deficiency on the cellular composition of atherosclerotic lesions in ApoE−/− mice. Representative images of carotid atherosclerotic lesion composition in mice from each group by staining with Oil red O, smooth muscle cell <i>α</i>-actin (SMC <i>α</i>-actin), CD68, or collagen. Quantification of Oil red O+, SMC <i>α</i>-actin+, CD68+, and collagen+, areas relative to the total plaque area. Scale <svg height="9.51429pt" id="M38" style="vertical-align:-0.2063894pt" version="1.1" viewbox="-0.0498162 -9.3079 50.9592 9.51429" width="50.9592pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M152 404V712C115 698 54 683 7 677V654C71 648 73 642 73 579V24C128 -2 179 -12 220 -12C353 -12 471 92 471 238C471 357 381 449 274 449C262 449 249 446 233 439L152 404ZM152 374C170 384 202 393 230 393C313 393 382 326 382 213C382 97 330 26 246 26C194 26 165 62 158 81C154 91 152 101 152 116V374Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.669,0)"><path d="M433 39L423 65C413 59 399 54 387 54C370 54 352 69 352 114V299C352 352 342 392 307 422C285 440 255 449 225 449C168 437 102 399 75 379C56 365 44 353 44 339C44 315 69 296 87 296C101 296 111 303 116 319C124 349 133 371 145 385C156 397 171 404 190 404C241 404 275 364 275 291V274C253 256 180 229 120 209C65 190 39 159 39 110C39 47 88 -12 159 -12C189 -12 237 25 277 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Nur77 Deficiency Exacerbates Macrophage NLRP3 Inflammasome-Mediated Inflammation and Accelerates Atherosclerosis 