Nur77 Deficiency Exacerbates Macrophage NLRP3 Inflammasome-Mediated Inflammation and Accelerates Atherosclerosis

Figure 8

Graphic illustration of the role of Nur77 in NLRP3 inflammasome-mediated inflammation and atherogenesis. Nur77 directly transcriptionally inhibits NLRP3 expression and attenuates macrophage NLRP3 inflammasome-mediated inflammatory responses, thereby slowing atherosclerotic plaque progression.