Association of Serum Homocysteine with Cardiovascular and All-Cause Mortality in Adults with Diabetes: A Prospective Cohort Study

Table 4

Predictive value of baseline Hcy for 10-year total and heart-related mortality in patients with preexisting diabetes.

Model	Reference	Reference+Hcy	Reference+CRP
Likelihood ratio test	—	<0.001	0.074
AIC	11118.2	11106.1	11117.0
BIC	11185.9	11179.5	11190.3
Harrell’s C-index	0.763	0.766	0.764
NRI	—	0.253	0.188
IDI	—	0.011	0.003

Reference model included age, sex, smoking status, BMI, hypertension, cancer, cardiovascular disease, the ratio of TC/HDL-C, eGFR, UACR, HbAc1, diabetic duration, and diabetic complications. All statistics were estimated based on the unweighted logistic regression analysis. Each additional model is compared to the reference model. AIC: Akaike information criterion; BIC: Bayesian information criterion; CRP: C-reactive protein; Hcy: homocysteine; IDI: integrated discrimination improvement; NRI: net reclassification index.