Pyrocatechol Alleviates Cisplatin-Induced Acute Kidney Injury by Inhibiting ROS Production

<div>Pyrocatechol protects against cisplatin-induced nephrotoxicity in vivo. (a) Schematic design of animal experiments showing mice induced with cisplatin or pretreated with pyrocatechol. (b) Blood urea nitrogen (BUN) and serum creatinine levels between the treatment groups. The four groups of mice were treated differently according to the experimental design chart. (c, d) The low panel shows semiquantitative scores for tubular injury (c); a micrograph of a representative H&amp;E-stained kidney section after hematoxylin and eosin (H&amp;E) staining (d). Scale bars, 50 <i>μ</i>M. (e) The levels of the renal injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and klotho mRNAs in kidney tissue were measured using real-time PCR. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Pyrocatechol Alleviates Cisplatin-Induced Acute Kidney Injury by Inhibiting ROS Production 