Pyrocatechol Alleviates Cisplatin-Induced Acute Kidney Injury by Inhibiting ROS Production

<div>Effects of pyrocatechol on cisplatin-induced inflammatory response and oxidative stress. (a, b) The levels of TNF-<i>α</i> and IL-6 in kidney tissue were measured using real-time PCR. (c–e) The levels of multiple chemokines, such as C–C motif chemokine ligand 2 (MCP-1), TNF superfamily member 12A (Fn14), and TNF superfamily member 12 (TWEAK), in kidney tissue was measured using real-time PCR. (f) The effect of pyrocatechol on glutathione (GSH) levels was evaluated. (g) The effect of pyrocatechol on superoxide dismutase (SOD) levels was evaluated. (h) The effect of pyrocatechol on catalase levels was evaluated. (i) Expression of glutathione peroxidase 4 (GPX4) in pyrocatechol-treated kidney tissue lysates by western blotting. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Pyrocatechol Alleviates Cisplatin-Induced Acute Kidney Injury by Inhibiting ROS Production 