DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma

<div>Effect of HCC culture medium on biological characteristics of ECDHCC-1 cells. (a and b) Cell viability (a) and cell apoptosis (b) of ECDHCC-1 cells were checked after incubation with HepG2-, HUH-7-, or THLE-2-conditioned media at the indicated ratio to ECDHCC-1 medium. (c–e) Fluorescence microscopy imaging of tube formation (c) and quantification of the number of nodes (d) and total tube length (e) by using tube formation assay utilizing the indicated medium with a 40% ratio to ECDHCC-1 medium were analyzed. (f and g) Wound healing (f) and quantification of the relative scratch width (g) of ECDHCC-1 cells treated with the indicated medium with a 40% ratio to ECDHCC-1 medium were performed. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma 