Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3<i>β</i>-Mediated Autophagy

<div>Hinokitiol inhibited autophagy flux induced by H2O2. (a, b) GSVA enrichment of GSE58486 and GSE6381. (c) RNA-sequencing of AC16 cells with different treatment as indicated, the data was analyzed by GSEA enrichment. (d) Detection of autophagic flux by mRFP-GFP-LC3 reporter system in AC16 cells. The microscopy images were merged with DAPI, GFP, and RFP fluorescence of cells. 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d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> (f) Protein expression of autophagy-related factor LC3B, Beclin-1, P62, and p-mTOR. Quantitative analysis of each bands was represented in numerical form under images, respectively. (g) The ratio of LC3II/LC3I according to western blotting results. ns, <span class="nowrap"><svg height="11.7782pt" id="M19" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 44.5261 11.7782" width="44.5261pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.342,0)"><path d="M512 230V281L75 514V456L453 256V254L75 55V-3L512 230Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.605,0)"><path 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3<i>β</i>-Mediated Autophagy 

Oxidative Medicine and Cellular Longevity

Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3β-Mediated Autophagy

Figure 3