Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3β-Mediated Autophagy

Figure 5

Hinokitiol increased p21 expression by inhibited GSK3β. (a) GSVA enrichment of GSE5406. (b) SVM-RFE algorithms in GSE5406 to predict the key genes responsible for heart failure after MI. (c) Partial least square discriminant analysis (PCA) for GSE5406 datasets to identify the vital genes responsible for heart failure after MI. (d) Volcano plot of fold changes of genes with human failing LV myocardium comparison with human nonfailing LV myocardium after MI. values were calculated using the Wald test. (e) Western blotting analysis: Hinokitiol increase p21 expression as demonstrated. Quantitative analysis of each bands was represented in numerical form under images, respectively.

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