Research Article
circPTP4A2-miR-330-5p-PDK2 Signaling Facilitates In Vivo Survival of HuMSCs on SF-SIS Scaffolds and Improves the Repair of Damaged Endometrium
Figure 6
MiR-330-5p overexpression impairs the circPTP4A2-enhanced mitochondrial metabolism in hypoxia-treated HuMSCs. (a) The rescue effects of miR-330-5p on the circPTP4A2-enhanced ATP content and (b) ATP synthase activity were analyzed using kits. (c) The rescue effects of miR-330-5p on the circPTP4A2-enhanced cell oxygen consumption rate (OCR) of HuMSCs were analyzed with the seahorse XF24 Extracellular Flux Analyzer. (d) Basal respiration, (e) ATP production, (f) maximal respiration, (g) spare respiratory capacity, (h) proton leak, and (i) nonmitochondrial respiration were analyzed. . relative to the indicated group.
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