Research Article

[Retracted] Network Pharmacology, Molecular Docking, and Experimental Validation to Unveil the Molecular Targets and Mechanisms of Compound Fuling Granule to Treat Ovarian Cancer

Table 2

Putative major ingredients and major targets of four herbs.

Chinese nameLatin nameNumber of ingredientsMajor ingredientsMajor targets

Fuzi (FZ)Aconitum napellus18(FZ02) hypaconitineABO
(FZ03) 11,14-eicosadienoic acidSOD2
(FZ05) demethyldelavaine AIL6ST
(FZ06) demethyldelavaine BDICER1
(FZ09) neokadsuranic acid BCDK2
(FZ12) 6-demethyldesolineCCND1
(FZ13) deoxyaconitineAKR1C1
(FZ14) ignavineABL1
(FZ15) isotalatizidineADAM17

Fuling (FL)Wolfiporia extensa (Peck) Ginns14(FL-01) (2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3,16-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-enoic acidGSTK1
(FL-02) trametenolic acidNCOA3
(FL-03) 7,9(11)-dehydropachymic acidMSN
(FL-04) cerevisterolSOD2
(FL-05) (2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3,16-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-isopropyl-hex-5-enoic acidSMARCA4
(FL-08) 3beta-hydroxy-24-methylene-8-lanostene-21-oic acidMUC1
(FL-09) pachymic acid
(FL-10) poricoic acid A
(FL-11) poricoic acid B
(FL-14) dehydroeburicoic acid

Chishao (CS)Radix paeoniae Rubra23(CS-03) stigmasterolCDK2
(CS-05) lactiflorinGSTK1
(CS-06) paeoniflorinMSN
(CS-07) paeoniflorin_qtNCOA3
(CS-12) 1-o-beta-d-glucopyranosyl-8-o-benzoylpaeonisuffrone_qtNDC80
(CS-15) benzoyl paeoniflorinSMARCA4
(CS-16) albiflorin
(CS-18) 4-ethyl-paeoniflorin_qt
(CS-19) 4-o-methyl-paeoniflorin_qt
(CS-21) paeoniflorigenone
(CS-22) evofolin B
(CS-23) isobenzoylpaeoniflorin

Mutouhui (MTH)Patrinia heterophylla DC root1(MTH) quercetinGJA1
NFATC1
GSTK1