Block of Proliferation 1 Promotes Proliferation, Invasion and Epithelial Mesenchymal Transformation in Gastric Cancer

Figure 1

BOP1 was up-regulated in gastric cancer (GC) and was associated with pathological grades based on online databases. (a) A total of 26 genes were differentially expressed (fold change>2 and P < 0.01) between tumor tissues and the adjacent normal tissues from two GEO profiles (GSE103236 and GSE118916). (b) The Heat map showed the relative expression of 26 genes in 5 paired GC tissues. (c) The Volcano map showed all differentially expressed genes. (d) BOP1 expression was compared between tumor tissues and the adjacent tissues from TCGA database(P < 0.0001). BOP1 expression was compared among (e) pathological grades (G1, G2 and G3) (P = 0.0096), (f) tumor location (antrum, fundus/body, gastroesophageal junction and cardia/proximal) (P = 0.0272). and (g) tumor weight group (P = 0.2393).

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