6-Gingerol Alleviates Ferroptosis and Inflammation of Diabetic Cardiomyopathy via the Nrf2/HO-1 Pathway

Figure 3

6-Gingerol attenuates STZ-induced ferroptosis and inflammation in vivo. (a) Prussian blue staining showing the level of iron ion. (b) Representative blots of FACL4 and GPX4 in the mouse heart (). (c, d) Histograms showing the fold change of FACL4 and GPX4. (e, f) The relative mRNA expression of FACL4 and GPX4 (); IL-1β (g), IL-6 (h), and TNF-α (i) activities in mouse serum (). Relative mRNA expression of IL-1β (j), IL-6 (k), and TNF-α (l) (). Heart tissue levels of SOD (m) and MDA (n) in mice. All data for proteins and mRNA was normalized to GAPDH before relative quantitative analysis. All values are expressed as . ^#, compared with the CON or 6-G group; , compared with the STZ group.

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