Antioxidative Stress and Antiapoptosis Effect of Chitosan Nanoparticles to Protect Cardiac Cell Damage on Streptozotocin-Induced Diabetic Rat

Figure 6

Histological study of administration of chitosan nanoparticle on streptozotocin-induced cardiac cell damage. The controls group showed normal morphology of the heart (a). The treatment streptozotocin group showed necrosis (indicated by black arrows) (b). Administration of chitosan nanoparticle 75 mg/kg BW and 150 mg/kg BW showed necrotic changes (c and d). However, administration of chitosan nanoparticle 300 mg/kg showed regeneration on cardiac cells damage (e) H and E, ×400.

(a)

(b)

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