Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System

<div><i>In vivo</i> cartilage regeneration in nude mice. (a) Gross morphology examination after hydrogels were injected subcutaneously into nude mice for 4 weeks. (b) Implants containing Kindlin-2 overexpression or knockdown chondrocytes cocultured with BMSCs were analyzed by wet weight. 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(c) Implants containing Kindlin-2 overexpression or knockdown chondrocytes cocultured with BMSCs were analyzed by Safranin O, Masson, collagen I, and collagen II staining confirmed by histological examination and immunohistochemical staining.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System 

Figure 2 | Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System 