High Glucose Promotes Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance and Invasion through Modulating ROS/MMP-3 Signaling Pathway

Figure 2

(a, b) K-M survival plots of PDA patients in TCGA cohort (A) and PDA gemcitabine users in Huashan cohort (B). (c) Heat map of the top 30 genes differentially expressed between the normal and the diabetic PDA patients (, ). (d) Volcano plot of DEGs between normal and diabetic PDA patients in TCGA database (up: upregulated genes, down: downregulated genes). (e) GSEA analysis of pathways enriched in the diabetic group. (f) GO and KEGG analyses of the pathways enriched in the DM group. (g) Pan-cancer analysis of MMP-3 expression between the normal tissue and the cancerous tissue based on the TCGA database (, , ).

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