High Glucose Promotes Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance and Invasion through Modulating ROS/MMP-3 Signaling Pathway

Figure 3

(a) Lasso regression analysis of DEGs between the normal and the DM groups. (b) ROS level of BxPC-3 cell lines under different glucose levels (HG: high glucose level group, MG: medium glucose level group, LG: low glucose level group). (c) Cell viability of BxPc-3 treated with 10 μmol/L gemcitabine for 24 h and 48 h. (d) Pancreatic cancer cell lines were treated with 10 μmol/L gemcitabine for 24 h under different glucose levels. (e) The apoptosis rate of different glucose groups under 10 μmol/L gemcitabine for 24 h (the lower right is the bar graph concluding the apoptosis between three groups). (f) Wound healing test of different glucose levels.

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