High Glucose Promotes Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance and Invasion through Modulating ROS/MMP-3 Signaling Pathway

Figure 5

(a) MMP-3 expression in normal pancreas tissue (left) and in PDA tissue (right) (downloaded from https://www.proteinatlas.org). (b, c) MMP-3 expression difference between normal () (left) and diabetic PDA patients () (right) (). (d) MMP-3 expression in high, medium, and low glucose group (e) MMP-3, beta-actin, and NOX4 expression in MMP-3 siRNAs treated group (MMP-3_Si01 and MMP-3_Si02), 20 μmol/L cordycepin, MMP-3 overexpression group (MMP-3_OVER), and normal control (NC_1) (, ns:>0.05). (f) The grey value of MMP-3/beta-actin and NOX4/beta-actin in Figure 1(e). (g) Apoptosis analysis of MMP-3 siRNAs treated group (MMP-3_Si01 and MMP-3_Si02), 20 μmol/L cordycepin, MMP-3 overexpression group (MMP-3_OVER), and normal control (NC_1 and NC_2). (h) The bar plot of the apoptotic rate in MMP-3_OVER, NC_1, NC_2, MMP-3_Si01 MMP-3_Si02, and 20 μmol/L cordycepin treated group.

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