[Retracted] Siglec-15 Regulates the Inflammatory Response and Polarization of Tumor-Associated Macrophages in Pancreatic Cancer by Inhibiting the cGAS-STING Signaling Pathway

Figure 1

Siglec-15 was expressed differently in M1 and M2 macrophages. (a) 20 ng/mL IL-4 was used to induce MФ into M2 type. The expression of the Siglec family in M2-type MФ was detected by qPCR. (b) Extract the total RNA of different tumor cells and TAMs and use qPCR assay to detect the expression level of Siglec-15. (c) Correlation analysis between the expression level of Siglec-15 and the overall survival (OS) of pancreatic tumors. (d) Siglec-15 transcription level of BMDMs stimulated by 100 ng/mL LPS and 20 ng/mL IFN-γ, or 20 ng/mL IL-4. (e) Siglec-15 protein level of BMDMs stimulated by 100 ng/mL LPS and 20 ng/mL IFN-γ, or 20 ng/mL IL-4. The experiments were repeated three times, and each experiment was triplicated.

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