[Retracted] Siglec-15 Regulates the Inflammatory Response and Polarization of Tumor-Associated Macrophages in Pancreatic Cancer by Inhibiting the cGAS-STING Signaling Pathway

Figure 6

Glut1-related glycolysis is involved in regulating macrophage inflammatory factors. (A) The peritoneal macrophages of wild-type and STING-KO mice were separately extracted and pre-incubated with Bay-876 for 30 minutes. After stimulation with IL-4, the expression of the cGAS-STING signaling pathway molecules changed. (b) The peritoneal macrophages of wild-type and STING-KO mice were extracted separately and pre-incubated with Bay-876 for 30 minutes. After stimulation with Pan-02 supernatant, the expression of cGAS-STING signaling pathway molecules changed. (c, d) After the above stimulation, the transcription level and release changes of inflammatory factors related to M1-macrophage were detected. The experiments were repeated three times, and each experiment was triplicated.

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