Research Article
[Retracted] Siglec-15 Regulates the Inflammatory Response and Polarization of Tumor-Associated Macrophages in Pancreatic Cancer by Inhibiting the cGAS-STING Signaling Pathway
Figure 7
Siglec-15 knockout inhibits the growth of subcutaneous transplanted tumors in mice. (a, b) Six to 8 weeks of wild-type and Siglec-15 KO mice, 200 μL of tumor cells was injected subcutaneously, the tumor volume was calculated and statistics (), and the tumor was peeled off and photographed. (c) In the survival curve experiment, the survival of mice was observed and recorded every day from the 20th day (). (d) Take mouse lymph nodes and count the tumor nodules in the lymph nodes. (e, f) Six- to 8-week-old wild-type mice were selected for macrophage and tumor cell co-injection model (200 μL, 1 : 1). The tumor was measured once in 5 days for recording and stripped and photographed. ; ; . The experiments were repeated three times, and each experiment was triplicated.
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |