Mammalian Sterile 20-Like Kinase 1 Mediates Neuropathic Pain Associated with Its Effects on Regulating Mitophagy in Schwann Cells

Figure 1

Mst1 knockdown alleviated CCI-induced heat hyperalgesia and mechanical allodynia in rats. (a) Quantitative analysis of PWL (s) and PWT (g). , vs the CCI+si-NC group at the same time point; . Statistical significance was determined by two-way repeated measures ANOVA, followed by Bonferroni’s post hoc test. (b) Protein expression of Mst1 with GAPDH as a loading control. ; . Statistical significance was determined by one-way ANOVA, followed by Bonferroni’s post hoc test. All data were expressed as the . CCI+si-NC: injured sciatic nerves were treated with scrambled siRNA as negative control; CCI+si-Mst1: injured sciatic nerves were treated with Mst1 siRNA.

(a)

(b)