Mammalian Sterile 20-Like Kinase 1 Mediates Neuropathic Pain Associated with Its Effects on Regulating Mitophagy in Schwann Cells

Figure 2

Mst1 knockdown protected the sciatic nerve from CCI-induced myelin degeneration. (a) TEM: representative images of the sciatic nerve. Black arrows point to myelin and stars refer to axon. 5800x. Scale bar: 5 μm. (b) Quantitative analysis of G-ratio. ; . Statistical significance was determined by one-way ANOVA, followed by Bonferroni’s post hoc test. All data were expressed as the . (c) Representative images of P0 staining. 400x. Scale bar: 50 μm. (d) Representative images of S100 staining. 400x. Scale bar: 50 μm. (e) Quantitative analysis of the number of S100-positive cells per sciatic nerve. ; . Statistical significance was determined by one-way ANOVA, followed by Bonferroni’s post hoc test. All data were expressed as the . CCI+si-NC: injured sciatic nerves were treated with scrambled siRNA as negative control; CCI+si-Mst1: injured sciatic nerves were treated with Mst1 siRNA.

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