Research Article
circHtra1/miR-3960/GRB10 Axis Promotes Neuronal Loss and Immune Deficiency in Traumatic Brain Injury
Figure 5
IGF-1 reduces circHtra1 via ADAR1. (a) IGF-1 is immunoprecipitated with htra1 in HEK cells, and this effect is blocked by AG1024. (b) circHtra1 expression in neurons treated with KA, IGF-1, ADAR1, and their inhibitors (, 3.162, and 8.503, respectively, ). (c, d) Expression of ADAR1 in neurons treated with KA, IGF-1, ADAR1, and their inhibitors (, 3.142, and 6.074, respectively, ). (e, f) Expression of GRB10 in neurons treated with KA, IGF-1, ADAR1, and their inhibitors (, 2.162, and 7.230, respectively, ). , #, &.
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