Exploring the Resistance Mechanisms of Distal D835V Mutation in FLT3 to Inhibitors

Figure 1

The structural features to differentiate the active and inactive states of FLT3. (a) Crystal structure of inactive FLT3 (PDB code: 4RT7); the cocrystallized ligand is shown in slate sphere. (b) Crystal structure of active FLT3 (PDB code: 6JQR); the cocrystallized ligand is shown in orange sphere. Both in (a) and (b), the D835V mutations are shown in magenta sphere. (c) 2D chemical structures of sorafenib and crenolanib.

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(b)

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