Exploring the Resistance Mechanisms of Distal D835V Mutation in FLT3 to Inhibitors

Figure 11

Alignment of the binding pocket between (a) 4RT7-WT+sorafenib (cyan) and 4RT7-D835V+sorafenib (wheat) and (b) 6JQR-WT+crenolanib (violet) and 6JQR-D835V+crenolanib (lemon).

(a)

(b)