Exploring the Resistance Mechanisms of Distal D835V Mutation in FLT3 to Inhibitors

Figure 6

Binding free energies of 4RT7-WT+sorafenib (blue), 4RT7-D835V+sorafenib (brown), 6JQR-WT+crenolanib (violet), and 6JQR-D835V+crenolanib (green). The total energy is composed of several different types of interactions, including coulomb, covalent, H-bond, lipophilic, packing, SolvGB, and vdW interactions.