Exploring the Resistance Mechanisms of Distal D835V Mutation in FLT3 to Inhibitors

Figure 8

MD-predicted structures of the 4RT7-sorafenib complexes. (a) 4RT7-WT+sorafenib and (b) 4RT7-D835V+sorafenib. 4RT7-WT backbone is shown as cyan cartoons, and 4RT7-D835V backbone is shown as wheat cartoons. Sorafenib is shown as orange ball-sticks. Magenta-dashed lines represent hydrogen bonds, and gray-dashed lines represent Pi-Pi stacking interactions.

(a)

(b)