Exploring the Resistance Mechanisms of Distal D835V Mutation in FLT3 to Inhibitors

Figure 9

MD-predicted structures of the 6JQR-crenolanib complexes. (a) 6JQR-WT+crenolanib and (b) 6JQR-D835V+crenolanib. 6JQR-WT backbone is shown as violet cartoons, and 6JQR-D835V backbone is shown as lemon cartoons. Crenolanib is shown as wheat ball-sticks. Magenta-dashed lines represent hydrogen bonds, and gray-dashed lines represent Pi-Pi stacking interactions.

(a)

(b)