KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca²⁺ Regulation and Oxidative Stress Inhibition

Figure 1

KCNH6 regulated hepatic glucose metabolism in Kcnh6 knockout mice. (a) Detection of the mRNA expression level of Kcnh6 in wild-type (WT) and Kcnh6 knockout (KO) mice using qRT-PCR (). (b) Western blot results showing protein levels (). Disruption of glucose metabolism in KO mice was assessed by evaluating (c) body weight (), (d) performing glucose tolerance test ( for the WT group; for the KO group), and (e) evaluating insulin tolerance test in mice (). (f) Western blot results showing the expression of G6pase, PEPCK, IRS2, and Glut2 in mice (). (g) G6pase, PEPCK, IRS2, and Glut2 expression in mouse liver tissues as determined by qRT-PCR (). , , and vs. WT. Statistical comparisons were calculated using (a, c–e) Mann–Whitney test and (b, f, g) one unpaired-sample -test.

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