KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca²⁺ Regulation and Oxidative Stress Inhibition

Figure 4

KCNH6 reduced intracellular ROS and mitochondrial superoxide production. ROS production in (a) HepG2 cells or (b) H₂O₂-treated HepG2 cells as detected by flow cytometry (). (c) ROS in mouse livers were detected by DHE staining ( for the WT group; for the KO group). (d) Detection of mitochondrial superoxide in WT and Kcnh6 KO mice ( for the WT group; for the KO group). and vs. the Ctrl group. ^# and ^## vs. the Kcnh6 group. Statistical comparisons were calculated using the (a, b) Mann–Whitney test and (c, d) unpaired-sample -test.

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