Mycophenolic Acid Induces the Intestinal Epithelial Barrier Damage through Mitochondrial ROS

Figure 1

Effect of MMF on the body weight and feces of mice. KM mice were randomly divided into two groups, the control group received saline and the MMF group received MMF (500 mg/kg) for 21 consecutive days, and then analyzed for changes in mice body weight (a) and differences in fecal water content (b). The ileum section was stained with H&E ((c) 100x/200x), and the villus height and crypt depth were measured by persons unrelated to this experiment (d). Data are expressed as the , in each group; , significantly different from the control.

(a)

(b)

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(d)