Mycophenolic Acid Induces the Intestinal Epithelial Barrier Damage through Mitochondrial ROS

<div>MMF induces apoptosis in vivo. KM mice were randomly divided into two groups, the control group received saline and the MMF group received MMF (500 mg/kg) for 21 consecutive days, and then, the expression of Bax/Bcl-2, cleaved caspase-3/caspase-3 in intestine tissue was detected by Western blot (a). Red arrows indicate that the cells incorporating BrdU are distributed in the crypt (b) (400x). 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The bar represents 20 <i>μ</i>m.</div>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Mycophenolic Acid Induces the Intestinal Epithelial Barrier Damage through Mitochondrial ROS 