Mycophenolic Acid Induces the Intestinal Epithelial Barrier Damage through Mitochondrial ROS

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left">Genes</td><td class="align_center">Forward primer (5<svg height="11.4859pt" id="M4" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 3.89517 11.4859" width="3.89517pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g></svg>–3<span class="nowrap"><svg height="11.4859pt" id="M5" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 3.89517 11.4859" width="3.89517pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g></svg>)</span></td><td class="align_center">Reverse primer (5<svg height="11.4859pt" id="M6" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 3.89517 11.4859" width="3.89517pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g></svg>–3<span class="nowrap"><svg height="11.4859pt" id="M7" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 3.89517 11.4859" width="3.89517pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g></svg>)</span></td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">GAPDH</td><td class="align_center">CAAGGTCATCCATGACAACTTTG</td><td class="align_center">GTCCACCACCCTGTTGCTGTAG</td></tr><tr><td class="align_left">Occludin</td><td class="align_center">ACAAGCGGTTTTATCCAGAGTC</td><td class="align_center">GTCATCCACAGGCGAAGTTAAT</td></tr><tr><td class="align_left">ZO-1</td><td class="align_center">CAACATACAGTGACGCTTCACA</td><td class="align_center">CACTATTGACGTTTCCCCACTC</td></tr><tr><td class="align_left">NOX 1</td><td class="align_center">GGAAACCGTGTCAGTCCTCC</td><td class="align_center">AACCACTCACGACAACAAGTTTA</td></tr><tr><td class="align_left">NOX 2</td><td class="align_center">TTCCAGTGCGTGTTGCTCGAC</td><td class="align_center">GATGGCGGTGTGCAGTGCTAT</td></tr><tr><td class="align_left">NOX 4</td><td class="align_center">GGATCACAGAAGGTCCCTAGCAG</td><td class="align_center">GCGGCTACATGCACACCTGAGAA</td></tr><tr><td class="align_left">p22phox</td><td class="align_center">TGTGGTGAAGCTTTTCGGGC</td><td class="align_center">GGATGGCTGCCAGCAGATAGAT</td></tr><tr><td class="align_left">p67phox</td><td class="align_center">CTATCTGGGCAAGCCTACGGTT</td><td class="align_center">CACAAAGCCAAACAATACGCG</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Oxidative Medicine and Cellular Longevity

tab1

Table 1

Table 1: Mycophenolic Acid Induces the Intestinal Epithelial Barrier Damage through Mitochondrial ROS 