[Retracted] DNA Topoisomerase II-α Regulated by miR-22-5p Promotes Hepatocellular Carcinoma Invasion and Migration through the Hippo Pathway

Figure 1

Genomic analysis of TOPs in HCC and WGCNA predicted biological pathways associated with TOP2A. On the basis of GSE121248’s expression profile, WGCNA was used to cluster genes that were highly connected with high TOP2A group and low TOP2A group. (a) OncoPrint visual summary of change on a query of TOPs and the high mutation rate of TOPs in HCC patients were detected (cBioPortal). (b) The cluster dendrogram of coexpression network modules. (c) The gene clusters obtained by the WGCNA method. (d) Significantly enriched biological process of the co-expressed genes in yellow module. (e) A network diagram showing significantly enriched biological process of the coexpressed genes in the yellow module using Metascape.

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