Research Article

[Retracted] DNA Topoisomerase II-α Regulated by miR-22-5p Promotes Hepatocellular Carcinoma Invasion and Migration through the Hippo Pathway

Figure 7

TOP2A overexpression reverse the effect of miR-22-5p. (a, b) qRT-PCR and western blot analysis exposed the TOP2A mRNA and protein level of HCC cell lines (MHCC97L and BEL-7404) transfected with miR-Ctrl+vector, miR-22-5p mimics+vector, or miR-22-5p mimics+TOP2A. (c) Wound healing assays of HCC cells treated with miR-Ctrl+vector, miR-22-5p+vector, and miR-22-5p+TOP2A. (d) Transwell invasion assay of HCC cells treated with miR-Ctrl+vector, miR-22-5p+vector, and miR-22-5p+TOP2A. The bar graphs show the number of migrating and invasive cells after 24 h. Data are shown as ; , , and .
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