Research Article
[Retracted] DNA Topoisomerase II-α Regulated by miR-22-5p Promotes Hepatocellular Carcinoma Invasion and Migration through the Hippo Pathway
Table 1
Information on the nine prospective drugs with significant scores for hepatocellular carcinoma treatment.
| | Drug name | PubChem CID | Molecular formula | Classification | Docking score | SPa | XPb |
| | Trametinib | 11707110 | C26H23FIN5O4 | Protein kinase inhibitor
Antineoplastic agents
Immunomodulating agent | -6.885 | -6.885 | -4.976 | | Selumetinib | 10127622 | C17H15BrClFN4O3 | Tyrosine kinase inhibitors | -6.164 | -6.172 | -6.844 | | Refametinib (RDEA119) | 44182295 | C19H20F3IN2O5S | Inhibitor of mitogen-activated ERK kinase | -5.403 | -5.405 | -7.441 | | PD-0325901 | 9826528 | C16H14F3IN2O4 | ERK MAPK signaling | -6.213 | -6.213 | -7.227 | | Dabrafenib | 44462760 | C23H20F3N5O2S2 | Reversible ATP-competitive kinase inhibitor | -4.725 | -7.726 | -6.128 | | Navitoclax | 24978538 | C47H55ClF3N5O6S3 | Bcl-2 antagonist | -7.429 | -7.588 | -5.757 | | Teniposide | 452548 | C32H32O13S | Topoisomerase II inhibitors
Immunomodulating agents | -4.725 | -4.726 | -4.803 | | Etoposide | 36462 | C29H32O13 | Topoisomerase II inhibitors
Antineoplastic agents | -4.994 | -4.994 | -4.078 | | Neopeltolide | 16115403 | C31H46N2O9 | Inhibitor of mitochondrial ATP synthesis coupled proton transport | -5.752 | -5.752 | -5.216 |
|
|
aSP: standard precision; bXP: extraprecision.
|
