M1 Microglia Induced Neuronal Injury on Ischemic Stroke via Mitochondrial Crosstalk between Microglia and Neurons

Figure 1

The major assumption of the present study. When IS occurred, more unhealthy mitochondria were secreted from M1 microglia and transferred into neurons for triggering mitochondria-mediated damage of neurons, thus aggravating ischemia-induced injury by enlarging infarct area and lowering neurological performance in transient middle cerebral artery occlusion (tMCAO) rats.