Association of Visit-to-Visit Variability in Fasting Plasma Glucose with Digestive Cancer Risk

Table 2

Risks of total digestive cancers according to quartiles of FPG variability assessed by SD.

Variable	HR (95% CI) according to quartiles of variability of FPG
	Quartile 1	Quartile 2	Quartile 3	Quartile 4
Event,	213 (0.86)	244 (0.99)	299 (1.23)	347 (1.41)
IR	0.92	1.07	1.33	1.51
Cox regression models
Model 1	1 (reference)	1.342 (1.117-1.614)	1.557 (1.305-1.856)	1.425 (1.201-1.692)
value	<0.0001^†	0.0017	<0.0001	<0.0001
Model 2	1 (reference)	1.342 (1.117-1.613)	1.554 (1.303-1.853)	1.391 (1.163-1.663)
value	<0.0001^†	0.0017	<0.0001	0.0003
Model 3	1 (reference)	1.341 (1.116-1.612)	1.551 (1.301-1.850)	1.387 (1.16-1.659)
value	<0.0001^†	0.0018	<0.0001	0.0003

IR (incidence rate) presented as per 1000 person-years. ^† for trend. Model 1: adjusted for age and sex. Model 2: model 1 + LDL-C, baseline FPG, antihypertensive drugs, hypoglycemic drugs, hypertension, and diabetes mellitus. Model 3: model 2 + BMI, current smoking, current drinking, physical exercise, and family history of cancer. Abbreviations: CI: confidence interval; FPG: fasting plasma glucose; HR: hazard ratio; SD: standard deviation.