BHF177 Suppresses Diabetic Neuropathic Pain by Blocking PKC/CaMKII/ERK1/2/CREB Signaling Pathway through Activating GABA<sub>B</sub> Receptor

<div>Schematic map of the regulatory role of BHF177 in DNP. BHF177 suppresses NMDA receptor NR2B subunit expression by activating GABA<sub>B</sub> receptors to block the PKC/CaMKII/ERK1/2/CREB signaling pathway, thus inhibiting DNP.</div>

Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: BHF177 Suppresses Diabetic Neuropathic Pain by Blocking PKC/CaMKII/ERK1/2/CREB Signaling Pathway through Activating GABA<sub>B</sub> Receptor 

Oxidative Medicine and Cellular Longevity

BHF177 Suppresses Diabetic Neuropathic Pain by Blocking PKC/CaMKII/ERK1/2/CREB Signaling Pathway through Activating GABAB Receptor

Figure 6

BHF177 Suppresses Diabetic Neuropathic Pain by Blocking PKC/CaMKII/ERK1/2/CREB Signaling Pathway through Activating GABA_B Receptor