Irisin Ameliorates Oxidative Stress-Induced Injury in Pancreatic Beta-Cells by Inhibiting Txnip and Inducing Stat3-Trx2 Pathway Activation

<div>In vivo Irisin administration prevented HFD-induced Trx2 activation and oxidative stress. (a) The expression of Trx2, Txnip, p-Stat3, and Stat3 was detected by immunoblotting. <i>β</i>-Actin was an internal standard. (b) Trx2 activity in the pancreas was measured by insulin disulfide reduction assay [<a href="/journals/omcl/2022/4674215/#B16">16</a>]. (c) Pancreatic MDA content analysis in different groups. (d) Analysis of pancreas GPx activity in different groups. (e) Analysis of pancreas SOD activity in different groups. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Irisin Ameliorates Oxidative Stress-Induced Injury in Pancreatic Beta-Cells by Inhibiting Txnip and Inducing Stat3-Trx2 Pathway Activation 