Paeoniflorin Upregulates Mitochondrial Thioredoxin of Schwann Cells to Improve Diabetic Peripheral Neuropathy Indicated by 4D Label-Free Quantitative Proteomics

Table 2

Mitochondrial interactome of Trx2 in rat Schwann cells regulated by PF.

Protein accession	Protein description	HG_PF/HG ratio	Regulated type	HG_PF/HG value	Gene name
B2RZD6	NDUFA4, mitochondrial complex-associated	2.623	Up	0.0172	Ndufa4
A0A0H2UHT6	40S ribosomal protein S18	1.641	Up	0.0015	Rps18
P20788	Cytochrome b-c1 complex subunit Rieske, mitochondrial	1.398	Up	0.0091	Uqcrfs1
P15999	ATP synthase subunit alpha, mitochondrial	1.21	Up	0.0218	Atp5f1a
O88767	Protein/nucleic acid deglycase DJ-1	1.195	Up	0.0225	Park7
Q66HF1	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	1.189	Up	0.0269	Ndufs1
Q75Q41	Mitochondrial import receptor subunit TOM22 homolog	1.154	Up	0.0025	Tomm22
F1M953	Stress-70 protein, mitochondrial	1.154	Up	0.0062	Hspa9
Q5XIJ3	Isocitrate dehydrogenase [NAD] subunit, mitochondrial	1.133	Up	0.0145	Idh3g
A0A0G2JVH4	MICOS complex subunit MIC60	1.127	Up	0.0036	Immt
Q9ER34	Aconitate hydratase, mitochondrial	1.055	Up	0.0306	Aco2
P04785	Protein disulfide-isomerase	0.931	Down	0.0044	P4hb
Q9Z0V5	Peroxiredoxin-4	0.884	Down	0.0019	Prdx4
O35244	Peroxiredoxin-6	0.863	Down	0.0048	Prdx6
P07632	Superoxide dismutase [Cu-Zn]	0.777	Down	0.0388	Sod1
Q5XIT9	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	0.733	Down	0.0222	Mccc2
A0A0G2K1W9	Lactate dehydrogenase D	0.38	Down	0.0414	Ldhd