[Retracted] DSC2 Suppresses the Metastasis of Gastric Cancer through Inhibiting the BRD4/Snail Signaling Pathway and the Transcriptional Activity of β-Catenin

Figure 6

DSC2 suppressed the nuclear translocation of β-catenin via inhibiting γ-catenin competitive binding to E-cadherin with β-catenin. (a) After knocking down and stably overexpressing DSC2 gene of MGC-803 cells, the expression of β-catenin in nucleus was determined by Western blot assay. Data are presented as from three separate experiments. vs. BC. vs. NC (or Lenti-NC) group. (b) After stably expressing DSC2 gene of MGC-803 cells, Co-IP assay was performed to analyze the interaction of DSC2/γ-catenin and DSC2/β-catenin by DSC2. (c and d) After stably expressing or knocking down DSC2 gene of MGC-803 cells, Co-IP assay was performed to analyze the interaction of E-cadherin/γ-catenin and E-cadherin/β-catenin by E-cadherin. The data were presented as , . , vs. NC (or Lenti-NC) group.

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