Ruscogenins Improve CD-Like Enteritis by Inhibiting Apoptosis of Intestinal Epithelial Cells and Activating Nrf2/NQO1 Pathway

Figure 1

RUS activated the Nrf2/NQO1 pathway in vitro and in vivo. (a–d) Expression levels of proteins associated with Nrf2/NQO1 signaling pathways in colon mucosal samples as determined by WB. The mice in the RUS group were coadministered with TNBS and RUS. (e–h) Expression levels of proteins associated with the Nrf2/NQO1 signaling pathway in organoids from LPS-treated mice as determined by WB. Organoids in the RUS groups were simultaneously cocultured with RUS and LPS for 24 hours. The experiments were repeated 3 times (), and the most typical result is shown. Data are presented as the (^※, compared with the WT group; ^#, compared with the RUS (1 mg) group; ^▽, compared with the control group; ^▼, compared with the RUS (10 μm) group).

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