Silencing TUFM Inhibits Development of Monocrotaline-Induced Pulmonary Hypertension by Regulating Mitochondrial Autophagy via AMPK/mTOR Signal Pathway

<div>Absence of TUFM improved the apoptosis and reduced the proliferation of PASMCs. (a) TUFM, Bax, and Bcl2 expression under hypoxia condition. (b–d) Densitometry data represent the intensity of each group. (e) Cell viability tested by CCK-8 under hypoxia condition. (f) Quantification of proliferation level in smooth muscle cell by EdU assay kit. (g) Cell proliferation activity of each group under hypoxia. Scale bar: 50 <i>μ</i>m. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Silencing TUFM Inhibits Development of Monocrotaline-Induced Pulmonary Hypertension by Regulating Mitochondrial Autophagy via AMPK/mTOR Signal Pathway 

Figure 5 | Silencing TUFM Inhibits Development of Monocrotaline-Induced Pulmonary Hypertension by Regulating Mitochondrial Autophagy via AMPK/mTOR Signal Pathway 