Suppressive Effect of Tetrahydrocurcumin on Pseudomonas aeruginosa Lipopolysaccharide-Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO-1 Pathways in Microglial Cells

Figure 5

THC inhibits iNOS, COX-2, and p-NFκB expressions in P. a. LPS-stimulated BV2 microglial cells. (a) BV2 microglial cells were pretreated without (mock) or with THC (10, 20, or 40 μM) for 1.5 h following stimulation with P. a. LPS (0.1 μg/ml) for 24 h. Western blotting showed the protein expression of iNOS, COX-2, p-NFκB, and GAPDH. Statistical results of (b) iNOS, (c) COX-2, and (d) p-NFκB p50 were shown. The experimental quantitative data are presented as (). Bars with the same letter represent no significant difference between the groups. Bars with different letters indicate a statistically significant () difference between the groups.

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