Suppressive Effect of Tetrahydrocurcumin on <i>Pseudomonas aeruginosa</i> Lipopolysaccharide-Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO-1 Pathways in Microglial Cells

<div>Conclusion of this study. THC blocks <i>P. a.</i> LPS–induced oxidative responses by increasing Nrf2-HO-1 expression which attenuates the iNOS, COX-2, and p-NF<i>κ</i>B expression. THC also inhibits the level of <i>P. a.</i> LPS–prompted JAK-STAT signaling and the inflammatory mediators IL-6, TNF-<i>α</i>, MIP-2, and IP-10 productions. Collectively, THC is a potent anti-inflammatory agent in brain encephalitis.</div>

Oxidative Medicine and Cellular Longevity

fig8

Figure 8

Figure 8: Suppressive Effect of Tetrahydrocurcumin on <i>Pseudomonas aeruginosa</i> Lipopolysaccharide-Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO-1 Pathways in Microglial Cells 

Figure 8 | Suppressive Effect of Tetrahydrocurcumin on Pseudomonas aeruginosa Lipopolysaccharide-Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO-1 Pathways in Microglial Cells 