MKK4 Knockdown Plays a Protective Role in Hemorrhagic Shock-Induced Liver Injury through the JNK Pathway

Figure 7

MKK4 downregulation suppresses the JNK/c-JUN and HIF-1α pathway. (a) Representative Western blot images of phosphorylated JNK/c-JUN and total JNK/c-JUN in the livers of rats after resuscitation. (b) Quantification of p-JNK and total JNK protein expression and the ratio of these two proteins in rat livers. (c) Quantification of p-c-JUN and total c-JUN expression and the ratio of these two proteins in the livers of HS rats. (d, e) The relative mRNA and protein expressions of HIF-1α were detected in rat livers. Values are presented as , for each group.

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