[Retracted] si-PDGFRβ-Loaded Exosomes Suppress the Progression of Glioma by Inhibiting the Oxidative Associated PI3K/Akt/EZH2 Signaling Pathway

Figure 2

The effects of silencing PDGFRβ on tumor inhibition of U251 cells. (a) U251 cell viability was measured by CCK-8 after transfecting with si-NC or si-PDGFRβ at 0, 24 h, 48 h, and 72 h. (b) EdU detection showed that si-PDGFRβ induced apoptosis. (c) FACS analysis showed that si-PDGFRβ induced apoptosis. (d) Immunoblot analysis showed the levels of the proapoptotic protein of Bax and cleaved caspase-3 and antiapoptotic protein of Bcl-2. (e) Wound healing test showed that si-PDGFRβ inhibited the migration of glioma cells. (f) Transwell assay results showed that downregulation of PDGFR revealed caspase-cell migration and invasion in glioma. (g) There are indications that si-PDGFRβ lowered MMP2 and MMP9, the hall marker protein of tumor invasion and metastasis by immunoblot analysis (, , and vs. si-NC group).

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